Associations Among Sodium Intake, Endothelial Dysfunction, and Endothelial Damage Biomarkers in Hypertension

Endothelial damage/dysfunction and hypertension in pregnancy.

Hypertension is one of the most common medical conditions complicating pregnancy, with significant implications on maternal and perinatal morbidity and mortality. Abnormalities in placentation have been implicated as the primary pathology responsible for the development of hypertension during pregnancy and its effects such as pre-eclampsia and eclampsia. With advancing research, the focus is no...

Endothelial dysfunction and hypertension.

Endothelial dysfunction in pulmonary hypertension.

The pathogenesis of pulmonary hypertension (PH) involves a complex and multifactorial process. Endothelial dysfunction seems to play an integral role in mediating the structural changes in the pulmonary vasculature. Disordered endothelial cell proliferation along with concurrent neoangiogenesis, when exuberant, results in the formation of glomeruloid structures known as the plexiform lesions, w...

AKT participates in endothelial dysfunction in hypertension.

BACKGROUND In hypertension, reduced nitric oxide production and blunted endothelial vasorelaxation are observed. It was recently reported that AKT phosphorylates and activates endothelial nitric oxide synthase and that impaired kinase activity may be involved in endothelial dysfunction. METHODS AND RESULTS To identify the physiological role of the kinase in normotensive Wistar-Kyoto rats (WKY...

Contribution to Hypertension and Endothelial Dysfunction

Copyright © 2007 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/CIRCULATIONAHA.106.665836 2007;115;1269-1274; originally published online Feb 26, 2007; Circulation David M. Kaye Zhiyong Yang, Kylie Venardos, Emma Jones, Brian J. Morris, Jaye Chin-Dust...